DISPARATE GENE-EXPRESSION OF CHEMOTACTIC CYTOKINES BY HUMAN MONONUCLEAR PHAGOCYTES

被引：72

作者：

STRIETER, RM

CHENSUE, SW

STANDIFORD, TJ

BASHA, MA

SHOWELL, HJ

KUNKEL, SL

机构：

[1] HENRY FORD HOSP,DEPT INTERNAL MED,DIV PULM MED,DETROIT,MI 48202

[2] PFIZER INC,DEPT IMMUNOL,GROTON,CT

[3] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48104

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90893-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemotactic cytokines are becoming increasingly recognized as important participants in the coordinate recruitment of specific inflammatory cells. In this manuscript we present data demonstrating that LPS challenged human mononuclear phagocytic cells can express mRNA for neutrophil chemotactic factor/interleukin-8 ( NCF IL-8), but do not express mRNA for monocyte chemotactic protein (MCP). The expression of NCF IL-8 mRNA was time and dose dependent. This identical stimulus response was also found in peripheral blood neutrophils. These studies demonstrate a disparate production of chemotactic cytokines by macrophages and exemplify the dynamic nature of the chemotactic response. © 1990.

引用

页码：886 / 891

页数：6

共 9 条

[1] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].