INHIBITION OF IL-1-BETA EXPRESSION IN THP-1 CELLS BY PROBUCOL AND TOCOPHEROL

被引：88

作者：

AKESON, AL

WOODS, CW

MOSHER, LB

THOMAS, CE

JACKSON, RL

机构：

[1] Merrell Dow Research Institute, Cincinnati

来源：

ATHEROSCLEROSIS | 1991年 / 86卷 / 2-3期

关键词：

ATHEROGENESIS; PROBUCOL; INTERLEUKIN-1; TOCOPHEROL; THP-1; CELLS;

D O I：

10.1016/0021-9150(91)90222-O

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cytokine interleukin-1, IL-1, likely plays an important role in the early stages of atherogenesis. The possible action of probucol and tocopherol on the expression and secretion of IL-1-beta was investigated using the human monocytic leukemia cell line, THP-1. Both probucol and D-alpha-tocopherol inhibit the phorbol ester-induced release of IL-1-beta without altering differentiation. Analysis of IL-1-beta mRNA levels revealed that probucol and tocopherol had an inhibitory effect on the activation of expression of the IL-1-beta gene. The data suggest that the beneficial effects of probucol may be related to inhibition of IL-1 at an early phase of atherosclerotic plaque formation.

引用

页码：261 / 270

页数：10

共 40 条

[1] TRANSCRIPTIONAL ACTIVATION OF THE LIPOPROTEIN-LIPASE AND APOLIPOPROTEIN-E GENES ACCOMPANIES DIFFERENTIATION IN SOME HUMAN MACROPHAGE-LIKE CELL-LINES [J].