NITRIC-OXIDE - A PHYSIOLOGICAL MEDIATOR OF PENILE ERECTION

被引：1007

作者：

BURNETT, AL

LOWENSTEIN, CJ

BREDT, DS

CHANG, TSK

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,725 N WOLFE ST,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT UROL,BALTIMORE,MD 21205

[5] JOHNS HOPKINS UNIV,SCH MED,DEPT CARDIOL,BALTIMORE,MD 21205

来源：

SCIENCE | 1992年 / 257卷 / 5068期

关键词：

D O I：

10.1126/science.1378650

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nitric oxide (NO) is a cytotoxic agent of macrophages, a messenger molecule of neurons, and a vasodilator produced by endothelial cells. NO synthase, the synthetic enzyme for NO, was localized to rat penile neurons innervating the corpora cavernosa and to neuronal plexuses in the adventitial layer of penile arteries. Small doses of NO synthase inhibitors abolished electrophysiologically induced penile erections. These results establish NO as a physiologic mediator of erectile function.

引用

页码：401 / 403

页数：3

共 42 条

[1] PENILE ERECTION - IN SEARCH OF A NEUROTRANSMITTER [J].