CODING REGION POLYMORPHISMS OF HUMAN T-CELL RECEPTOR V-BETA-6.9 AND V-BETA-21.4

被引：26

作者：

HANSEN, T ^{[1
]}

RONNINGEN, KS ^{[1
]}

PLOSKI, R ^{[1
]}

KIMURA, A ^{[1
]}

THORSBY, E ^{[1
]}

机构：

[1] KYUSHU UNIV, MED INST BIOREGULAT, DEPT GENET, FUKUOKA 812, JAPAN

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1992年 / 36卷 / 02期

关键词：

D O I：

10.1111/j.1365-3083.1992.tb03101.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two new TCR V-beta coding region polymorphisms were identified: V-beta-6.9a/b and V-beta-21.4a/b. In both cases, a single nucleotide difference gives rise to an amino acid exchange. Genomic typing by the PCR/sequence-specific oligonucleotide probing technique was performed to study a possible contribution of these two new polymorphisms in susceptibility to autoimmune diseases. However, there was no association with insulin-dependent diabetes mellitus, rheumatoid arthritis, juvenile rheumatoid arthritis, multiple sclerosis, myasthenia gravis or coeliac disease. On the other hand, significant differences were found between Caucasoid and Oriental populations in frequencies of the V-beta-6.9 and V-beta-21.4 alleles.

引用

页码：285 / 290

页数：6

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