STUDIES ON THE HUMAN T-CELL RECEPTOR ALPHA/BETA VARIABLE REGION GENES .2. IDENTIFICATION OF 4 ADDITIONAL V-BETA SUBFAMILIES

被引：178

作者：

FERRADINI, L ^{[1
]}

ROMANROMAN, S ^{[1
]}

AZOCAR, J ^{[1
]}

MICHALAKI, H ^{[1
]}

TRIEBEL, F ^{[1
]}

HERCEND, T ^{[1
]}

机构：

[1] INST GUSTAVE ROUSSY, INSERM,U333,HEMATOIMMUNOL LAB, 39 RUE CAMILLE DESMOULINS, F-94805 VILLEJUIF, FRANCE

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 04期

关键词：

D O I：

10.1002/eji.1830210412

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human T cell receptor (TcR) beta chain gene segment diversity has been studied using the anchored-polymerase chain reaction. Three hundred and fifty C-beta-specific transcripts derived from peripheral lymphocytes were analyzed. Transcripts including V-D-beta-1-J-beta-2-C2 sequences were found with a high frequency (> 10%), suggesting that "illegitimate" joinings may constitute a cis-complementing rearrangement mechanism capable of substantially increasing the TcR beta chain combinatorial diversity. Twelve previously undescribed V-beta gene segments have been identified. Five of them delineate four novel V-beta subfamilies (V-beta-w21: two members, V-beta-w22, 23, 24: one member) which all have a murine homologue. The additional seven gene segments belong to the V-beta-5, V-beta-6, V-beta-12 and V-beta-13 subfamilies. In addition, the sequences of two known V-beta-7 and V-beta-9 gene segments have been extended. Together, the present data support the view that the contribution of the beta chain combinatorial diversity to the TcR alpha/beta variability has not yet been fully appreciated.

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收藏

页码：935 / 942

页数：8

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