TAU-PROTEIN AND PAIRED HELICAL FILAMENTS OF ALZHEIMERS-DISEASE

被引：30

作者：

CROWTHER, RA ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(05)80153-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant advances have recently been made in understanding the nature of the Alzheimer paired helical filament. This appears to consist entirely of abnormally phosphorylated microtubule-associated protein Tau. Filaments resembling those found in Alzheimer's disease have been assembled in vitro from fragments of Tau protein spanning the microtubule-binding repeat region.

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页码：202 / 206

页数：5

相关论文

共 25 条

[11] CLONING AND SEQUENCING OF THE CDNA-ENCODING A CORE PROTEIN OF THE PAIRED HELICAL FILAMENT OF ALZHEIMER-DISEASE - IDENTIFICATION AS THE MICROTUBULE-ASSOCIATED PROTEIN TAU [J].

GOEDERT, M ;

WISCHIK, CM ;

CROWTHER, RA ;

WALKER, JE ;

KLUG, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (11) :4051-4055

[12] TAU-PROTEINS OF ALZHEIMER PAIRED HELICAL FILAMENTS - ABNORMAL PHOSPHORYLATION OF ALL 6 BRAIN ISOFORMS [J].

GOEDERT, M ;

SPILLANTINI, MG ;

CAIRNS, NJ ;

CROWTHER, RA .

NEURON, 1992, 8 (01) :159-168

[13]

Goedert M, 1991, Curr Opin Neurobiol, V1, P441, DOI 10.1016/0959-4388(91)90067-H

[14] P42 MAP KINASE PHOSPHORYLATION SITES IN MICROTUBULE-ASSOCIATED PROTEIN TAU ARE DEPHOSPHORYLATED BY PROTEIN PHOSPHATASE-2A1 - IMPLICATIONS FOR ALZHEIMERS-DISEASE [J].

GOEDERT, M ;

COHEN, ES ;

JAKES, R ;

COHEN, P .

FEBS LETTERS, 1992, 312 (01) :95-99

[15]

GREENBERG SG, 1992, J BIOL CHEM, V267, P564

[16] A PREPARATION OF ALZHEIMER PAIRED HELICAL FILAMENTS THAT DISPLAYS DISTINCT TAU-PROTEINS BY POLYACRYLAMIDE-GEL ELECTROPHORESIS [J].

GREENBERG, SG ;

DAVIES, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5827-5831

[17] THE ALZHEIMER-LIKE PHOSPHORYLATION OF TAU-PROTEIN REDUCES MICROTUBULE BINDING AND INVOLVES SER-PRO AND THR-PRO MOTIFS [J].

GUSTKE, N ;

STEINER, B ;

MANDELKOW, EM ;

BIERNAT, J ;

MEYER, HE ;

GOEDERT, M ;

MANDELKOW, E .

FEBS LETTERS, 1992, 307 (02) :199-205

[18]

HASEGAWA M, 1992, J BIOL CHEM, V267, P17047

[19] IDENTIFICATION OF 3-REPEAT AND 4-REPEAT TAU-ISOFORMS WITHIN THE PHF IN ALZHEIMERS-DISEASE [J].

JAKES, R ;

NOVAK, M ;

DAVISON, M ;

WISCHIK, CM .

EMBO JOURNAL, 1991, 10 (10) :2725-2729

[20] MICROTUBULE BUNDLING BY TAU PROTEINS INVIVO - ANALYSIS OF FUNCTIONAL DOMAINS [J].

KANAI, Y ;

CHEN, JG ;

HIROKAWA, N .

EMBO JOURNAL, 1992, 11 (11) :3953-3961