THE EFFECT OF CONTEXT ON SYNONYMOUS CODON USAGE IN GENES WITH LOW CODON USAGE BIAS

被引：55

作者：

BULMER, M

机构：

[1] Department of Statistics, Oxford OX1 3TG

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 10期

关键词：

D O I：

10.1093/nar/18.10.2869

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of neighbouring bases on the usage of synonymous codons in genes with low codon usage bias in yeast and E. coli is examined. The codon adaptation index is employed to identify a group of genes in each organism with low codon usage bias, which are likely to be weakly expressed. A similar pattern is found in complementary sequences with respect to synonymous usage of A vs G or of U vs C. It is suggested that this may reflect an effect of context on mutation rates in weakly expressed genes. © 1990 Oxford University Press.

引用

页码：2869 / 2873

页数：5

共 22 条

[11] CONTEXTUAL CONSTRAINTS ON SYNONYMOUS CODON CHOICE [J].

LIPMAN, DJ ;

WILBUR, WJ .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 163 (03) :363-376

[12] CODON CONTEXT EFFECTS IN MISSENSE SUPPRESSION [J].

MURGOLA, EJ ;

PAGEL, FT ;

HIJAZI, KA .

JOURNAL OF MOLECULAR BIOLOGY, 1984, 175 (01) :19-27

[13] MONONUCLEOTIDE THROUGH HEXANUCLEOTIDE COMPOSITION OF THE ESCHERICHIA-COLI GENOME - A MARKOV-CHAIN ANALYSIS [J].

PHILLIPS, GJ ;

ARNOLD, J ;

IVARIE, R .

NUCLEIC ACIDS RESEARCH, 1987, 15 (06) :2611-2626

[14] AN EVOLUTIONARY PERSPECTIVE ON SYNONYMOUS CODON USAGE IN UNICELLULAR ORGANISMS [J].

SHARP, PM ;

LI, WH .

JOURNAL OF MOLECULAR EVOLUTION, 1986, 24 (1-2) :28-38

[15] CODON USAGE IN REGULATORY GENES IN ESCHERICHIA-COLI DOES NOT REFLECT SELECTION FOR RARE CODONS [J].

SHARP, PM ;

LI, WH .

NUCLEIC ACIDS RESEARCH, 1986, 14 (19) :7737-7749

[16] THE CODON ADAPTATION INDEX - A MEASURE OF DIRECTIONAL SYNONYMOUS CODON USAGE BIAS, AND ITS POTENTIAL APPLICATIONS [J].

SHARP, PM ;

LI, WH .

NUCLEIC ACIDS RESEARCH, 1987, 15 (03) :1281-1295

[17] SYNONYMOUS CODON USAGE IN BACILLUS-SUBTILIS REFLECTS BOTH TRANSLATIONAL SELECTION AND MUTATIONAL BIASES [J].

SHIELDS, DC ;

SHARP, PM .

NUCLEIC ACIDS RESEARCH, 1987, 15 (19) :8023-8040

[18] CONSTRAINTS ON CODON CONTEXT IN ESCHERICHIA-COLI GENES - THEIR POSSIBLE ROLE IN MODULATING THE EFFICIENCY OF TRANSLATION [J].

SHPAER, EG .

JOURNAL OF MOLECULAR BIOLOGY, 1986, 188 (04) :555-564

[19]

Stuart A, 1987, KENDALLS ADV THEORY, V1

[20] ON GENETIC BASIS OF VARIATION AND HETEROGENEITY OF DNA BASE COMPOSITION [J].

SUEOKA, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (04) :582-&

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