T-CELLS AND EOSINOPHILS IN THE PATHOGENESIS OF ASTHMA

被引：537

作者：

CORRIGAN, CJ

KAY, AB

机构：

[1] C.J. Corrigan and A.B. Kay are, the Dept of Allergy and Clinical Immunology, National Heart and Lung Institute, London, SW3 6LY, Dovehouse Street

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 12期

关键词：

D O I：

10.1016/0167-5699(92)90026-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Persistent asthma is characterized by chronic inflammation of the bronchial mucosa, where T cells and eosinophils are prominent. This article summarizes the evidence that asthmatic bronchial inflammation is initiated and propagated by cytokines secreted by activated T cells and other cells, and describes how the release of specific cytokines could result in local preferential accumulation and activation of eosinophils.

引用

页码：501 / 507

页数：7

共 63 条

[1]

ABUGHAZALEH RI, 1989, J IMMUNOL, V142, P2393

[2] EOSINOPHIL MEDIATED AND EOSINOPHIL GRANULE MEDIATED PNEUMOCYTE INJURY [J].

AYARS, GH ;

ALTMAN, LC ;

GLEICH, GJ ;

LOEGERING, DA ;

BAKER, CB .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1985, 76 (04) :595-604

[3] LYMPHOCYTES-T AND ACTIVATED EOSINOPHILS IN AIRWAY MUCOSA IN FATAL ASTHMA AND CYSTIC-FIBROSIS [J].

AZZAWI, M ;

JOHNSTON, PW ;

MAJUMDAR, S ;

KAY, AB ;

JEFFERY, PK .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (06) :1477-1482

[4]

AZZAWI M, 1990, AM REV RESPIR DIS, V142, P1410

[5] MECHANISM OF EOSINOPHILIA .2. ROLE OF LYMPHOCYTE [J].

BASTEN, A ;

BEESON, PB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1970, 131 (06) :1288-&

[6] IDENTIFICATION OF LYMPHOCYTES-T, MACROPHAGES, AND ACTIVATED EOSINOPHILS IN THE BRONCHIAL-MUCOSA IN INTRINSIC ASTHMA - RELATIONSHIP TO SYMPTOMS AND BRONCHIAL RESPONSIVENESS [J].

BENTLEY, AM ;

MENZ, G ;

STORZ, C ;

ROBINSON, DS ;

BRADLEY, B ;

JEFFERY, PK ;

DURHAM, SR ;

KAY, AB .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (02) :500-506

[7] ACTIVATED LYMPHOCYTES-T AND EOSINOPHILS IN THE BRONCHIAL-MUCOSA IN ISOCYANATE-INDUCED ASTHMA [J].

BENTLEY, AM ;

MAESTRELLI, P ;

SAETTA, M ;

FABBRI, LM ;

ROBINSON, DS ;

BRADLEY, BL ;

JEFFERY, PK ;

DURHAM, SR ;

KAY, AB .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (04) :821-829

[8] EOSINOPHILIC INFLAMMATION IN ASTHMA [J].

BOUSQUET, J ;

CHANEZ, P ;

LACOSTE, JY ;

BARNEON, G ;

GHAVANIAN, N ;

ENANDER, I ;

VENGE, P ;

AHLSTEDT, S ;

SIMONYLAFONTAINE, J ;

GODARD, P ;

MICHEL, FB .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1033-1039

[9] EOSINOPHILS, T-LYMPHOCYTES, MAST-CELLS, NEUTROPHILS, AND MACROPHAGES IN BRONCHIAL BIOPSY SPECIMENS FROM ATOPIC SUBJECTS WITH ASTHMA - COMPARISON WITH BIOPSY SPECIMENS FROM ATOPIC SUBJECTS WITHOUT ASTHMA AND NORMAL CONTROL SUBJECTS AND RELATIONSHIP TO BRONCHIAL HYPERRESPONSIVENESS [J].

BRADLEY, BL ;

AZZAWI, M ;

JACOBSON, M ;

ASSOUFI, B ;

COLLINS, JV ;

IRANI, AMA ;

SCHWARTZ, LB ;

DURHAM, SR ;

JEFFERY, PK ;

KAY, AB .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1991, 88 (04) :661-674

[10] CYTOKINES IN SYMPTOMATIC ASTHMA AIRWAYS [J].

BROIDE, DH ;

LOTZ, M ;

CUOMO, AJ ;

COBURN, DA ;

FEDERMAN, EC ;

WASSERMAN, SI .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (05) :958-967

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