IDENTIFICATION OF GENES ENCODING 2 CAPSID PROTEINS (VP24 AND VP26) OF HERPES-SIMPLEX VIRUS TYPE-1

被引：83

作者：

DAVISON, MD

RIXON, FJ

DAVISON, AJ

机构：

[1] MRC, VIROL UNIT, INST VIROL, CHURCH ST, GLASGOW G11 5JR, SCOTLAND

[2] ICI PHARMACEUT PLC, DEPT BIOTECHNOL, MACCLESFIELD SK10 4TG, CHESHIRE, ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-10-2709

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The capsid of herpes simplex virus type 1 is composed of seven proteins. VP5, VP19C, VP22a and VP23 have been shown previously to be the products of genes UL19, UL38, UL26.5 and UL18, respectively. The genes encoding VP21, VP24 and VP26 have not been identified to date. We have determined amino acid sequences of fragments of isolated capsid proteins generated by partial cleavage with CNBr. The results confirm the gene assignments for VP5, VP19C and VP23. They also show that VP26 is the product of gene UL35 and that VP24 contains the protease domain present in the N-terminal portion of the UL26-encoded protein. VP21 was not investigated, but we suggest that it is the C-terminal portion of the UL26-encoded protein remaining after release of VP24 and that it thus corresponds to a form of VP22a extended at the N terminus.

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页码：2709 / 2713

页数：5

相关论文

共 42 条

[21] THE HERPES-SIMPLEX VIRUS-1 GENE ENCODING A PROTEASE ALSO CONTAINS WITHIN ITS CODING DOMAIN THE GENE ENCODING THE MORE ABUNDANT SUBSTRATE [J].

LIU, FY ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1991, 65 (10) :5149-5156

[22] THE PROMOTER, TRANSCRIPTIONAL UNIT, AND CODING SEQUENCE OF HERPES-SIMPLEX VIRUS-1 FAMILY 35 PROTEINS ARE CONTAINED WITHIN AND IN FRAME WITH THE UL26 OPEN READING FRAME [J].

LIU, FY ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1991, 65 (01) :206-212

[23] DIFFERENTIATION OF MULTIPLE DOMAINS IN THE HERPES-SIMPLEX VIRUS-1 PROTEASE ENCODED BY THE UL26 GENE [J].

LIU, FY ;

ROIZMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2076-2080

[24]

MATSUDAIRA P, 1987, J BIOL CHEM, V262, P10035

[25] THE COMPLETE DNA-SEQUENCE OF THE LONG UNIQUE REGION IN THE GENOME OF HERPES-SIMPLEX VIRUS TYPE-1 [J].

MCGEOCH, DJ ;

DALRYMPLE, MA ;

DAVISON, AJ ;

DOLAN, A ;

FRAME, MC ;

MCNAB, D ;

PERRY, LJ ;

SCOTT, JE ;

TAYLOR, P .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :1531-1574

[26] STRUCTURE OF THE HERPES-SIMPLEX VIRUS CAPSID - EFFECTS OF EXTRACTION WITH GUANIDINE-HYDROCHLORIDE AND PARTIAL RECONSTITUTION OF EXTRACTED CAPSIDS [J].

NEWCOMB, WW ;

BROWN, JC .

JOURNAL OF VIROLOGY, 1991, 65 (02) :613-620

[27] USE OF AR+ PLASMA-ETCHING TO LOCALIZE STRUCTURAL PROTEINS IN THE CAPSID OF HERPES-SIMPLEX VIRUS TYPE-1 [J].

NEWCOMB, WW ;

BROWN, JC .

JOURNAL OF VIROLOGY, 1989, 63 (11) :4697-4702

[28] STUDIES OF MOLECULAR ANATOMY OF L-M CELL STRAIN OF EQUINE HERPES-VIRUS TYPE 1 - PROTEINS OF NUCLEOCAPSID AND INTACT VIRION [J].

PERDUE, ML ;

KEMP, MC ;

RANDALL, CC ;

OCALLAGH.DJ .

VIROLOGY, 1974, 59 (01) :201-216

[29] PHYSICAL MAPPING AND NUCLEOTIDE-SEQUENCE OF A HERPES-SIMPLEX VIRUS TYPE-1 GENE REQUIRED FOR CAPSID ASSEMBLY [J].

PERTUISET, B ;

BOCCARA, M ;

CEBRIAN, J ;

BERTHELOT, N ;

CHOUSTERMAN, S ;

PUVIONDUTILLEUL, F ;

SISMAN, J ;

SHELDRICK, P .

JOURNAL OF VIROLOGY, 1989, 63 (05) :2169-2179

[30] PROCESSING OF THE HERPES-SIMPLEX VIRUS ASSEMBLY PROTEIN-ICP35 NEAR ITS CARBOXY TERMINAL END REQUIRES THE PRODUCT OF THE WHOLE OF THE UL26 READING FRAME [J].

PRESTON, VG ;

RIXON, FJ ;

MCDOUGALL, IM ;

MCGREGOR, M ;

ALKOBAISI, MF .

VIROLOGY, 1992, 186 (01) :87-98

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