学术探索
学术期刊
新闻热点
数据分析
智能评审

THE CURIOUS CASE OF PROTEIN SPLICING - MECHANISTIC INSIGHTS SUGGESTED BY PROTEIN SEMISYNTHESIS

被引：56
作者：
WALLACE, CJA
机构：
[1] Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
来源：
PROTEIN SCIENCE | 1993年 / 2卷 / 05期
关键词：
AUTOCATALYSIS; INTRONS; MOLECULAR EVOLUTION; POLYPROTEINS; PROTEIN SEMISYNTHESIS; PROTEIN SPLICING;
D O I：
10.1002/pro.5560020501
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The gradual accumulation of examples of protein splicing, in which a nested intervening sequence is spliced out of the interior of a polyprotein precursor, suggests that this curious phenomenon might prove to have universal phylogenetic distribution and biological significance. The known examples are reviewed, with the aim of establishing underlying patterns, and a generalized mechanism of autocatalytic protein splicing is proposed. The testable consequences of such a proposal and the possible evolutionary origins of the phenomenon are discussed.
引用
收藏
页码：697 / 705
页数：9
相关论文
共 37 条
[11]  
HIRATA R, 1990, J BIOL CHEM, V265, P6726
[12]   PROTEIN SPLICING REMOVES INTERVENING SEQUENCES IN AN ARCHAEA DNA-POLYMERASE [J].
HODGES, RA ;
PERLER, FB ;
NOREN, CJ ;
JACK, WE .
NUCLEIC ACIDS RESEARCH, 1992, 20 (23) :6153-6157
[13]   SYNTHESIS OF PEPTIDE-BONDS BY PROTEINASES - ADDITION OF ORGANIC COSOLVENTS SHIFTS PEPTIDE-BOND EQUILIBRIA TOWARD SYNTHESIS [J].
HOMANDBERG, GA ;
MATTIS, JA ;
LASKOWSKI, M .
BIOCHEMISTRY, 1978, 17 (24) :5220-5227
[14]   ENZYMATIC RESYNTHESIS OF THE HYDROLYZED PEPTIDE BOND(S) IN RIBONUCLEASE-S [J].
HOMANDBERG, GA ;
LASKOWSKI, M .
BIOCHEMISTRY, 1979, 18 (04) :586-592
[15]  
HOUGH R, 1987, J BIOL CHEM, V262, P8303
[16]  
JONNALAGADDA S, 1987, J BIOL CHEM, V262, P17750
[17]   PROTEIN SPLICING CONVERTS THE YEAST TFP1 GENE-PRODUCT TO THE 69-KD SUBUNIT OF THE VACUOLAR H+-ADENOSINE TRIPHOSPHATASE [J].
KANE, PM ;
YAMASHIRO, CT ;
WOLCZYK, DF ;
NEFF, N ;
GOEBL, M ;
STEVENS, TH .
SCIENCE, 1990, 250 (4981) :651-657
[18]   2 STRUCTURAL GENES ON DIFFERENT CHROMOSOMES ARE REQUIRED FOR ENCODING THE MAJOR SUBUNIT OF HUMAN RED-CELL GLUCOSE-6-PHOSPHATE-DEHYDROGENASE [J].
KANNO, H ;
HUANG, IY ;
KAN, YW ;
YOSHIDA, A .
CELL, 1989, 58 (03) :595-606
[19]   CHEMICAL SYNTHESIS OF PEPTIDES AND PROTEINS [J].
KENT, SBH .
ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 :957-989
[20]  
KULLMAN W, 1987, ENZYMATIC PEPTIDE SY
1234