THE CURIOUS CASE OF PROTEIN SPLICING - MECHANISTIC INSIGHTS SUGGESTED BY PROTEIN SEMISYNTHESIS

被引：56

作者：

WALLACE, CJA

机构：

[1] Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia

来源：

PROTEIN SCIENCE | 1993年 / 2卷 / 05期

关键词：

AUTOCATALYSIS; INTRONS; MOLECULAR EVOLUTION; POLYPROTEINS; PROTEIN SEMISYNTHESIS; PROTEIN SPLICING;

D O I：

10.1002/pro.5560020501

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gradual accumulation of examples of protein splicing, in which a nested intervening sequence is spliced out of the interior of a polyprotein precursor, suggests that this curious phenomenon might prove to have universal phylogenetic distribution and biological significance. The known examples are reviewed, with the aim of establishing underlying patterns, and a generalized mechanism of autocatalytic protein splicing is proposed. The testable consequences of such a proposal and the possible evolutionary origins of the phenomenon are discussed.

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收藏

页码：697 / 705

页数：9

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