GAMETIC IMPRINTING IN MAMMALS

被引：376

作者：

BARLOW, DP ^{[1
]}

机构：

[1] INST MOLEC PATHOL, DR BOHR GASSE 7, A-1030 VIENNA, AUSTRIA

来源：

SCIENCE | 1995年 / 270卷 / 5242期

关键词：

D O I：

10.1126/science.270.5242.1610

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Embryonic development in mammals is distinct from that in other vertebrates because it depends on a small number of imprinted genes that are specifically expressed from either the maternal or paternal genome. Why mammals are uniquely dependent on sexual reproduction and how this dependency is dictated at a molecular level are questions that have been intensively investigated during the past 2 years. Gene inactivation experiments have confirmed predictions that imprinted genes regulate embryonic and placental growth and that DNA methylation is part of the imprinting mechanism. Despite these considerable achievements, the reason why imprinted hemizygosity is used as a mechanism to regulate the intrauterine growth of mammalian embryos remains elusive.

引用

页码：1610 / 1613

页数：4

共 49 条

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