RHODOPSEUDOMONAS-SPHAEROIDES LIPID-A DERIVATIVES BLOCK INVITRO INDUCTION OF TUMOR-NECROSIS-FACTOR AND ENDOTOXIN TOLERANCE BY SMOOTH LIPOPOLYSACCHARIDE AND MONOPHOSPHORYL LIPID-A

被引：32

作者：

HENRICSON, BE

PERERA, PY

QURESHI, N

TAKAYAMA, K

VOGEL, SN

机构：

[1] UNIFORMED SERV UNIV HLTH SCI, DEPT MICROBIOL, 4301 JONES BRIDGE RD, BETHESDA, MD 20814 USA

[2] WILLIAM S MIDDLETON MEM VET ADM MED CTR, MYCOBACTERIOL RES LAB, MADISON, WI 53705 USA

[3] UNIV WISCONSIN, COLL AGR & LIFE SCI, DEPT BACTERIOL, MADISON, WI 53706 USA

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 10期

关键词：

D O I：

10.1128/IAI.60.10.4285-4290.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rhodopseudomonas (Rhodobacter) sphaeroides diphosphoryl lipid A is a relatively inert species of lipid A but has been shown to antagonize the effects of toxic lipopolysaccharide (LPS) both in vivo and in vitro. The antagonist and its monophosphoryl derivative were examined for the ability to block tumor necrosis factor synthesis and reverse tolerance induction in vitro in macrophage cultures stimulated with bioactive preparations of smooth LPS, rough LPS, diphosphoryl lipid A, and monophosphoryl lipid A. Inhibition of agonist activity and reversal of tolerance by these novel penta-acylated lipid A antagonists provides new insight into macrophage-LPS interactions.

引用

页码：4285 / 4290

页数：6