EVOLUTION OF THE P450-GENE SUPERFAMILY - ANIMAL PLANT WARFARE, MOLECULAR DRIVE AND HUMAN GENETIC-DIFFERENCES IN DRUG OXIDATION

被引：422

作者：

GONZALEZ, FJ ^{[1
]}

NEBERT, DW ^{[1
]}

机构：

[1] UNIV CINCINNATI,MED CTR,DEPT ENVIRONM HLTH,CINCINNATI,OH 45267

来源：

TRENDS IN GENETICS | 1990年 / 6卷 / 06期

关键词：

D O I：

10.1016/0168-9525(90)90174-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Drug-metabolizing enzymes, such as those encoded by the cytochrome P450 genes, are noted for their high degree of interspecies and intraspecies variability. We believe that much of this diversity is the result of continuous molecularly driven coevolution of plants producing phytoalexins and animals responding with new enzymes to detoxify these chemicals. One consequence of human P450 gene evolution is polymorphism in drug metabolism, leading to marked differences in the response of individuals to the toxic and carcinogenic effects of drugs and other environmental chemicals. © 1990.

引用

页码：182 / 186

页数：5

共 37 条

[31] 2 MUTANT ALLELES OF THE HUMAN CYTOCHROME-P-450DB1 GENE (P450C2D1) ASSOCIATED WITH GENETICALLY DEFICIENT METABOLISM OF DEBRISOQUINE AND OTHER DRUGS [J].

SKODA, RC ;

GONZALEZ, FJ ;

DEMIERRE, A ;

MEYER, UA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :5240-5243

[32] EVOLUTION OF REPEATED DNA SEQUENCES BY UNEQUAL CROSSOVER [J].

SMITH, GP .

SCIENCE, 1976, 191 (4227) :528-535

[33]

SONG BJ, 1989, J BIOL CHEM, V264, P3568

[34] THE OLDEST EUKARYOTIC CELLS [J].

VIDAL, G .

SCIENTIFIC AMERICAN, 1984, 250 (02) :48-57

[35]

VOGEL F, 1986, HUMAN GENETICS

[36]

WATKINS PB, 1986, J BIOL CHEM, V261, P6264

[37]

Williams R.T, 1974, BIOCHEM SOC T, V2, P359, DOI 10.1042/bst0020359

← 1 2 3 4 →