AGE-RELATED-CHANGES IN AORTIC ELASTICITY DETERMINED BY GATED RADIONUCLIDE ANGIOGRAPHY IN PATIENTS WITH SYSTEMIC HYPERTENSION OR HEALED MYOCARDIAL INFARCTS AND IN NORMAL SUBJECTS

We estimated the aortic volume elasticity (Ve), an index of aortic stiffness, using gated radionuclide angiography, and investigated age-related changes in aortic elasticity in 22 normal control subjects, 30 hypertensive patients and 36 patients with old myocardial infarction. Ve elasticity was calculated noninvasively as a ratio of the pressure change (dP) and the percent volume change (dV/Vo) determined by radionuclide angiography [Ve = dP/(dV/Vo)]. dV/Vo was calculated from the maximal and minimal counts in the aortic arch [dV/Vo = (maximum - minimum)/minimum]. Ve increased significantly with age in normal control subjects (r = 0.62, p < 0.001), hypertensive patients (r = 0.60, p < 0.001) and patients with old infarcts (r = 0.59, p < 0.001). The age-related increase in Ve was significantly greater in hypertensive patients, and that for patients with old myocardial infarcts tended to be greater than in control subjects. Thus, hypertension accelerates the decrease in aortic elasticity with aging. The greater decrease in aortic elasticity resulted in a significant age-related increase in pulse pressure in patients with hypertension and old myocardial infarction.