INCREASED SERUM GROWTH-HORMONE AND SOMATIC GROWTH IN ADULT HAMSTERS WITH HIPPOCAMPAL TRANSECTIONS

被引：22

作者：

BORER, KT

KELCH, RP

PEUGH, J

HUSEMAN, C

机构：

[1] UNIV MICHIGAN,DEPT PEDIAT,ANN ARBOR,MI 48109

[2] UNIV NEBRASKA,DEPT PEDIAT,OMAHA,NE 68101

来源：

NEUROENDOCRINOLOGY | 1979年 / 29卷 / 01期

关键词：

Growth; Growth hormone; Hippocampus; Homologous RIA for hamster growth hormone; Hyperphagia; Hypoactivity; Obesity; Septum;

D O I：

10.1159/000122901

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Somatic, endocrine, and behavioral correlates of growth and levels of voluntary running activity were measured in adult hamsters with hippocampal transections (HIPPO cuts) or in controls with transections of overlying cortex. Significant increase in serum concentration of growth hormone (GH) and decrease in pituitary concentration of GH were measured in HIPPO hamsters with a homologous radioimmunoassay method for hamster GH. HIPPO hamsters had increased: Serum insulin concentration in fed state, food consumption, ponderal and linear growth, and percentage of body fat. and decreased levels of voluntary activity. Similarities between growth acceleration after HIPPO cuts and lesions of rostral medial septum suggest that fibers interconnecting, or passing through, the hippocampal formation and septum inhibit growth in adult hamsters. © 1979 S. Karger AG, Basel.

引用

页码：22 / 33

页数：12

共 72 条

[61] ELECTROPHYSIOLOGICAL CONCOMITANTS OF EATING INDUCED FROM NEOCORTEX AND HIPPOCAMPUS BY ELECTRICAL-STIMULATION AND INJECTION OF KC1 OR NOREPINEPHRINE [J].