POTASSIUM ACTIVATION ASSOCIATED WITH INTRA-NEURONAL FREE CALCIUM

被引：79

作者：

ECKERT, R ^{[1
]}

TILLOTSON, D ^{[1
]}

机构：

[1] FRIDAY HARBOR LABS,FRIDAY HARBOR,WA 98250

来源：

SCIENCE | 1978年 / 200卷 / 4340期

关键词：

D O I：

10.1126/science.644308

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Relations between calcium entry and activation of a calcium-dependent outward current during depolarization were examined under voltage clamp in dorid giant neurons injected with the calcium-sensitive photoprotein aequorin. Activation kinetics and amplitude of the slow calcium-dependent component were both found to be related to the rate and extent of free calcium accumulation and to the electromotive force acting on potassium ions, independent of the calcium activation kinetics. This indicates that the activation of the calcium-dependent outward current is more closely related to the transient intracellular accumulation of free calcium ions than to the movement of calcium through the plasma membrane during depolarization. Copyright © 1978 AAAS.

引用

页码：437 / 439

页数：3

共 23 条

[11] CONTROL OF DELAYED OUTWARD POTASSIUM CURRENTS IN BURSTING PACE-MAKER NEURONS OF SNAIL, HELIX-POMATIA [J].