Stratification of the channel domain in neurotransmitter receptors

被引：75

作者：

Bertrand, Daniel ^{[1
]}

Galzi, Jean-Luc ^{[2
]}

Devillers-Thiery, Anne ^{[2
]}

Bertrand, Sonia ^{[1
]}

Changeux, Jean-Pierre ^{[2
]}

机构：

[1] Ctr Med Univ Geneva, Dept Physiol, CH-1211 Geneva 4, Switzerland

[2] Inst Pasteur, Unite Rech Associee, Ctr Natl Rech Sci D1284, F-74724 Paris 15, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1016/0955-0674(93)90141-C

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Analyses of the ionic pore of ligand-gated ion channels at the amino acid level reveal a structural and functional stratification of the M2 channel domain. Mutations in the equatorial and outer regions affect channel gating, whereas mutations of other amino acid rings alter ionic permeability or selectivity.

引用

页码：688 / 693

页数：6

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