CELL-DEATH BY APOPTOSIS AND ITS PROTECTIVE ROLE AGAINST DISEASE

被引：409

作者：

BURSCH, W

OBERHAMMER, F

SCHULTEHERMANN, R

机构：

[1] W. Barsch, F. Oberhammer and R. Schuhe-Hermann are all, the Institut für Tumorbiologie-Krebsforschung der Universität Wien, A1090 Wien

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 06期

关键词：

D O I：

10.1016/0165-6147(92)90077-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The involvement of cell death in control of tissue growth has long been neglected, but the description of apoptosis as cellular 'suicide', the functional opposite of mitosis, is now attracting more attention to this phenomenon. Physiologically unwanted cells are removed by apoptosis, and toxic chemicals and drugs may enhance or inhibit this type of cell death. These findings are providing new insights into the pathophysiology of a variety of diseases, and suggesting new therapeutic strategies.

引用

页码：245 / 251

页数：7

共 54 条

[21] RESPONSE OF INTESTINAL-CELLS OF DIFFERING TOPOGRAPHICAL AND HIERARCHICAL STATUS TO 10 CYTO-TOXIC DRUGS AND 5 SOURCES OF RADIATION [J].

IJIRI, K ;

POTTEN, CS .

BRITISH JOURNAL OF CANCER, 1983, 47 (02) :175-185

[22]

ITO N, 1991, CANCER RES, V51, P4080

[23] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].

KERR, JFR ;

WYLLIE, AH ;

CURRIE, AR .

BRITISH JOURNAL OF CANCER, 1972, 26 (04) :239-+

[24]

KRATOCHWIL K, 1989, DEV BIOL, V4, P315

[25] EXPRESSION OF TRANSFORMING GROWTH FACTOR-BETA IN THE RAT VENTRAL PROSTATE DURING CASTRATION-INDUCED PROGRAMMED CELL-DEATH [J].

KYPRIANOU, N ;

ISAACS, JT .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (10) :1515-1522

[26]

KYPRIANOU N, 1990, CANCER RES, V50, P3748

[27]

KYPRIANOU N, 1991, CANCER RES, V51, P162

[28] TREATMENT WITH ANTIANDROGENS INDUCES AN ANDROGEN-REPRESSED GENE IN THE RAT VENTRAL PROSTATE [J].

LEGER, JG ;

LEGUELLEC, R ;

TENNISWOOD, MPR .

PROSTATE, 1988, 13 (02) :131-142

[29]

LOCKSHIN RA, 1990, J GERONTOL, V45, P135

[30]

MCDONALD HR, 1990, NATURE, V343, P642

← 1 2 3 4 5 6 →