TARGETING OF NONEXPRESSED GENES IN EMBRYONIC STEM-CELLS VIA HOMOLOGOUS RECOMBINATION

被引:91
作者
JOHNSON, RS
SHENG, M
GREENBERG, ME
KOLODNER, RD
PAPAIOANNOU, VE
SPIEGELMAN, BM
机构
[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115
[3] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
[4] TUFTS UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02111
[5] TUFTS UNIV,SCH VET MED,BOSTON,MA 02111
关键词
D O I
10.1126/science.2506639
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1234 / 1236
页数:3
相关论文
共 29 条
[1]   TISSUE SPECIFIC EXPRESSION OF P422 PROTEIN, A PUTATIVE LIPID CARRIER, IN MOUSE ADIPOCYTES [J].
BERNLOHR, DA ;
DOERING, TL ;
KELLY, TJ ;
LANE, MD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (02) :850-855
[2]  
BERNLOHR DA, 1985, J BIOL CHEM, V260, P5563
[3]   FORMATION OF GERM-LINE CHIMERAS FROM EMBRYO-DERIVED TERATOCARCINOMA CELL-LINES [J].
BRADLEY, A ;
EVANS, M ;
KAUFMAN, MH ;
ROBERTSON, E .
NATURE, 1984, 309 (5965) :255-256
[4]   ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].
CAPECCHI, MR .
SCIENCE, 1989, 244 (4910) :1288-1292
[5]   A DEVELOPMENTALLY REGULATED MESSENGER-RNA FROM 3T3 ADIPOCYTES ENCODES A NOVEL SERINE PROTEASE HOMOLOG [J].
COOK, KS ;
GROVES, DL ;
MIN, HY ;
SPIEGELMAN, BM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6480-6484
[6]   DEVELOPMENTALLY REGULATED MESSENGER-RNAS IN 3T3-ADIPOCYTES - ANALYSIS OF TRANSCRIPTIONAL CONTROL [J].
COOK, KS ;
HUNT, CR ;
SPIEGELMAN, BM .
JOURNAL OF CELL BIOLOGY, 1985, 100 (02) :514-520
[7]   FOS AND JUN - THE AP-1 CONNECTION [J].
CURRAN, T ;
FRANZA, BR .
CELL, 1988, 55 (03) :395-397
[8]   NUCLEOPROTEIN COMPLEXES THAT REGULATE GENE-EXPRESSION IN ADIPOCYTE DIFFERENTIATION - DIRECT PARTICIPATION OF C-FOS [J].
DISTEL, RJ ;
RO, HS ;
ROSEN, BS ;
GROVES, DL ;
SPIEGELMAN, BM .
CELL, 1987, 49 (06) :835-844
[9]   THE ACTIVATION OF SPECIFIC GENE-TRANSCRIPTION IN THE ADIPOSE CONVERSION OF 3T3-CELLS [J].
DJIAN, P ;
PHILLIPS, M ;
GREEN, H .
JOURNAL OF CELLULAR PHYSIOLOGY, 1985, 124 (03) :554-556
[10]   TARGETED MUTATION OF THE HPRT GENE IN MOUSE EMBRYONIC STEM-CELLS [J].
DOETSCHMAN, T ;
MAEDA, N ;
SMITHIES, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) :8583-8587