CHOLESTEROL-RICH LDL PERFUSED AT PHYSIOLOGICAL LDL-CHOLESTEROL CONCENTRATION INDUCES PLATELET-AGGREGATION AND PAF-ACETYLHYDROLASE ACTIVATION

被引：21

作者：

CHUI, DH ^{[1
]}

MAROTTA, F ^{[1
]}

RAO, ML ^{[1
]}

LIU, DS ^{[1
]}

ZHANG, SC ^{[1
]}

IDEO, C ^{[1
]}

机构：

[1] OSPED NIGUARDA CA GRANDA,LIVER UNIT CRESPI,MILAN,ITALY

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1991年 / 45卷 / 01期

关键词：

LDL-PERFUSION; PLATELET AGGREGATION; PAF-ACETYLHYDROLASE;

D O I：

10.1016/0753-3322(91)90152-J

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of this research was to perform an in vivo study on the relationship between lipid oxide (LP), platelet aggregation and PAF-acetylhydrolase in a model using perfusion of cholesterol-rich LDL media diluted to physiological LDL-cholesterol concentration. Normal rabbits were infused with LDL (d 1.025-1.063 g/ml) extracted from rabbits previously fed either with standard food (I-LDL group), 1% cholesterol food (II-LDL group) or 1% cholesterol plus probucol (IV-LDL group). CU2+ modified II-LDL was also infused (III-LDL group). After dilution as above, LP increased significantly in III- and II-LDL media. After perfusion, LP significantly increased in III- and II-LDL groups as compared to baseline values and to control. Compared to the I-LDL group, PAF-acetylhydrolase and platelet aggregation significantly increased in III- and II-LDL groups. These data indicate the property of cholesterol- rich LDL to activate PAF-acetylhydrolase and enhance platelet aggregation, even when perfused through a medium containing a physiological LDL-cholesterol concentration.

引用

页码：37 / 42

页数：6

共 27 条

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