THIAMINE-DEPENDENT ENZYME CHANGES IN TEMPORAL CORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE

被引：145

作者：

BUTTERWORTH, RF

BESNARD, AM

机构：

[1] Laboratory of Neurochemistry, André-Viallet Clinical Research Center, Hôpital St-Luc (University of Montreal), Montreal, H2X 3J4, Quebec

来源：

METABOLIC BRAIN DISEASE | 1990年 / 5卷 / 04期

关键词：

ALZHEIMERS DISEASE; THIAMINE-DEPENDENT ENZYMES; THIAMINE; VITAMIN-B1; PYRUVATE DEHYDROGENASE COMPLEX; ALPHA-KETOGLUTARATE DEHYDROGENASE; TRANSKETOLASE; GLUTAMATE DEHYDROGENASE;

D O I：

10.1007/BF00997071

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activites of thiamine-dependent enzymes [pyruvate dehydrogenase (PDHC), alpha-ketoglutarate dehydrogenase (alpha-KGDH), and transketolase (TK)] were measured in autopsied samples of temporal cortex from six patients with Alzheimer's disease and from eight age-matched control subjects who were free from neurological or psychiatric diseases. Times from death to freezing of dissected material at - 70-degrees-C were matched. Significant decreases in PDHC (decreased by 70%; P < 0.01), alpha-KGDH (decreased by 70%; p < 0.01), and TK (decreased by 52%; P < 0.01) were observed in brain tissue from patients with Alzheimer's disease. In contrast, activities of glutamate dehydrogenase were within normal limits. These findings suggest a possible role for alterations of brain thiamine metabolism or utilization in Alzheimer's disease

引用

页码：179 / 184

页数：6