SELECTIVE EFFECT OF ACTINOMYCIN D ON FREE POLYRIBOSOMES OF MOUSE LIVER

被引：49

作者：

SARMA, DSR

REID, IM

SIDRANSKY, H

机构：

[1] Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 04期

关键词：

D O I：

10.1016/0006-291X(69)90344-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The administration of actinomycin D to fasted mice 12 hours before killing results in marked disaggregation of hepatic polyribosomes as determined by sucrose density gradients prepared from deoxycholate-treated postmitochondrial supernatants. This disaggregation of hepatic polyribosomes occurs in the free but not in the membrane-bound polyribosomes. Free, but not membrane-bound, polyribosomes of livers of actinomycin D-treated animals demonstrate decreased incorporation in vitro of 14C-leucine into proteins. © 1969.

引用

页码：582 / +

页数：1

共 16 条

[11] SYNTHESIS OF SERUM PROTEINS ON ATTACHED RATHER THAN FREE RIBOSOMES OF RAT LIVER [J].

REDMAN, CM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1968, 31 (06) :845-&

[12]

SIDRANSK.H, 1969, LAB INVEST, V20, P364

[13]

SIDRANSKY H, 1968, J BIOL CHEM, V243, P1123

[14] BREAKDOWN OF RAT-LIVER ERGOSOMES IN VIVO AFTER ACTINOMYCIN INHIBITION OF MESSENGER RNA SYNTHESIS [J].

STAEHELIN, T ;

WETTSTEIN, FO ;

NOLL, H .

SCIENCE, 1963, 140 (356) :180-&

[15] REFORMATION OF FUNCTIONAL LIVER POLYRIBOSOMES FROM RIBOSOME MONOMERS IN ABSENCE OF RNA SYNTHESIS [J].

STEWART, GA ;

FARBER, E .

SCIENCE, 1967, 157 (3784) :67-+

[16] DIRECT EVIDENCE FOR ALBUMIN BIOSYNTHESIS BY MEMBRANE BOUND POLYSOMES IN RAT LIVER [J].

TAKAGI, M ;

OGATA, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1968, 33 (01) :55-&

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