SELECTIVE EFFECT OF ACTINOMYCIN D ON FREE POLYRIBOSOMES OF MOUSE LIVER

被引：49

作者：

SARMA, DSR

REID, IM

SIDRANSKY, H

机构：

[1] Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 04期

关键词：

D O I：

10.1016/0006-291X(69)90344-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The administration of actinomycin D to fasted mice 12 hours before killing results in marked disaggregation of hepatic polyribosomes as determined by sucrose density gradients prepared from deoxycholate-treated postmitochondrial supernatants. This disaggregation of hepatic polyribosomes occurs in the free but not in the membrane-bound polyribosomes. Free, but not membrane-bound, polyribosomes of livers of actinomycin D-treated animals demonstrate decreased incorporation in vitro of 14C-leucine into proteins. © 1969.

引用

页码：582 / +

页数：1

共 16 条

[1]

BENEDETTI EL, 1966, LAB INVEST, V15, P196

[2] STUDIES ON FREE AND MEMBRANE-BOUND RIBOSOMES IN RAT LIVER .I. DISTRIBUTION AS RELATED TO TOTAL CELLULAR RNA [J].