MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME

被引：1019

作者：

CERRETTI, DP ^{[1
]}

KOZLOSKY, CJ ^{[1
]}

MOSLEY, B ^{[1
]}

NELSON, N ^{[1
]}

VANNESS, K ^{[1
]}

GREENSTREET, TA ^{[1
]}

MARCH, CJ ^{[1
]}

KRONHEIM, SR ^{[1
]}

DRUCK, T ^{[1
]}

CANNIZZARO, LA ^{[1
]}

HUEBNER, K ^{[1
]}

BLACK, RA ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV, JEFFERSON CANC INST, PHILADELPHIA, PA 19107 USA

来源：

SCIENCE | 1992年 / 256卷 / 5053期

关键词：

D O I：

10.1126/science.1373520

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin-1-beta (IL-1-beta) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1-beta to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.

引用

页码：97 / 100

页数：4