CLINICAL AND PHARMACOKINETIC EFFECTS OF A DIET RICH IN INSOLUBLE FIBER ON PARKINSON DISEASE

被引：90

作者：

ASTARLOA, R ^{[1
]}

MENA, MA ^{[1
]}

SANCHEZ, V ^{[1
]}

DELAVEGA, L ^{[1
]}

DEYEBENES, JG ^{[1
]}

机构：

[1] RAMON & CAJAL HOSP,DEPT INVEST,MADRID,SPAIN

来源：

CLINICAL NEUROPHARMACOLOGY | 1992年 / 15卷 / 05期

关键词：

PARKINSONS DISEASE; L-DOPA PHARMACOKINETICS; FIBER INTAKE;

D O I：

10.1097/00002826-199210000-00004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study, the effects of a diet rich in insoluble fiber (DRIF) on motor disability and the peripheral pharmacokinetics of orally administered L-dopa in Parkinsonian patients with marked constipation are analyzed. We found a useful effect of a DRIF on plasma L-dopa concentration and motor function. The greatest effect on the plasma L-dopa levels was found early (at 30 and 60 min) after oral administration. There was a relationship between the improvement of constipation and the higher bioavailability Of L-dopa. DRIF can be a coadjutant treatment in patients with Parkinson's disease.

引用

页码：375 / 380

页数：6

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