TAU-PROTEIN CONCENTRATIONS IN CEREBROSPINAL-FLUID OF PATIENTS WITH DEMENTIA OF THE ALZHEIMER-TYPE

被引：82

作者：

TATO, RE

FRANK, A

HERNANZ, A

机构：

[1] HOSP LA PAZ,SERV BIOQUIM,E-28046 MADRID,SPAIN

[2] HOSP LA PAZ,NEUROL SERV,MADRID,SPAIN

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1995年 / 59卷 / 03期

关键词：

CEREBROSPINAL FLUID; TAU PROTEIN; MSE TEST; AIZHEIMERS DISEASE; MULTIINFARCT DEMENTIA;

D O I：

10.1136/jnnp.59.3.280

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tau protein concentrations were measured in the CSF of 23 patients with dementia of the Alzheimer type (DAT), 36 patients with multi-infarct dementia (MID), and 23 control subjects. Tau protein concentrations were significantly higher in patients with DAT than in controls (P < 0.001) and patients with IMID (P < 0.001). A significantly positive correlation between CSF tau protein and glucose concentrations (r = 0.79, P < 0.001) and evolution of disease (r = 0.47, P < 0.05), and a negative correlation with Folstein's mental state examination test (r = -0.73, P < 0.001) were found in patients with DAT.

引用

页码：280 / 283

页数：4

共 25 条

[11] DIAGNOSIS OF ALZHEIMERS-DISEASE [J].