TAU-PROTEIN CONCENTRATIONS IN CEREBROSPINAL-FLUID OF PATIENTS WITH DEMENTIA OF THE ALZHEIMER-TYPE

被引：82

作者：

TATO, RE

FRANK, A

HERNANZ, A

机构：

[1] HOSP LA PAZ,SERV BIOQUIM,E-28046 MADRID,SPAIN

[2] HOSP LA PAZ,NEUROL SERV,MADRID,SPAIN

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1995年 / 59卷 / 03期

关键词：

CEREBROSPINAL FLUID; TAU PROTEIN; MSE TEST; AIZHEIMERS DISEASE; MULTIINFARCT DEMENTIA;

D O I：

10.1136/jnnp.59.3.280

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tau protein concentrations were measured in the CSF of 23 patients with dementia of the Alzheimer type (DAT), 36 patients with multi-infarct dementia (MID), and 23 control subjects. Tau protein concentrations were significantly higher in patients with DAT than in controls (P < 0.001) and patients with IMID (P < 0.001). A significantly positive correlation between CSF tau protein and glucose concentrations (r = 0.79, P < 0.001) and evolution of disease (r = 0.47, P < 0.05), and a negative correlation with Folstein's mental state examination test (r = -0.73, P < 0.001) were found in patients with DAT.

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页码：280 / 283

页数：4

相关论文

共 25 条

[1]

ADOLFSSON R, 1980, ACTA MED SCAND, V208, P387

[2] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].

ARRIAGADA, PV ;

GROWDON, JH ;

HEDLEYWHYTE, ET ;

HYMAN, BT .

NEUROLOGY, 1992, 42 (03) :631-639

[3] NEUROPATHOLOGICAL STAGING OF ALZHEIMER LESIONS AND INTELLECTUAL STATUS IN ALZHEIMERS AND PARKINSONS-DISEASE PATIENTS [J].

BANCHER, C ;

BRAAK, H ;

FISCHER, P ;

JELLINGER, KA .

NEUROSCIENCE LETTERS, 1993, 162 (1-2) :179-182

[4] NEUROPEPTIDE-Y IMMUNOREACTIVITY IS REDUCED IN CEREBRAL-CORTEX IN ALZHEIMERS-DISEASE [J].

BEAL, MF ;

MAZUREK, MF ;

CHATTHA, GK ;

SVENDSEN, CN ;

BIRD, ED ;

MARTIN, JB .

ANNALS OF NEUROLOGY, 1986, 20 (03) :282-288

[5] HUMAN CEREBROSPINAL-FLUID SOMATOSTATIN IN NEUROLOGIC DISEASE [J].

BEAL, MF ;

MAZUREK, MF ;

BLACK, PM ;

MARTIN, JB .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1985, 71 (01) :91-104

[6] REDUCED SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN CEREBRAL-CORTEX FROM CASES OF ALZHEIMER-DISEASE AND ALZHEIMER SENILE DEMENTIA [J].

DAVIES, P ;

KATZMAN, R ;

TERRY, RD .

NATURE, 1980, 288 (5788) :279-280

[7] AMINO-ACID CONCENTRATIONS IN CEREBROSPINAL-FLUID IN PRESENILE AND SENILE DEMENTIA OF ALZHEIMER TYPE AND MULTI-INFARCT DEMENTIA [J].

DEGRELL, I ;

HELLSING, K ;

NAGY, E ;

NIKLASSON, F .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1989, 9 (02) :123-135

[8] BIOCHEMICAL ASSAY OF ALZHEIMERS-DISEASE ASSOCIATED PROTEIN(S) IN HUMAN BRAIN-TISSUE - A CLINICAL-STUDY [J].

GHANBARI, HA ;

MILLER, BE ;

HAIGLER, HJ ;

ARATO, M ;

BISSETTE, G ;

DAVIES, P ;

NEMEROFF, CB ;

PERRY, EK ;

PERRY, R ;

RAVID, R ;

SWAAB, DF ;

WHETSELL, WO ;

ZEMLAN, FP .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (21) :2907-2910

[9] A SANDWICH ENZYME-IMMUNOASSAY FOR DETECTING AND MEASURING ALZHEIMERS-DISEASE ASSOCIATED PROTEINS IN HUMAN BRAIN-TISSUE [J].

GHANBARI, HA ;

KOZUK, T ;

MILLER, BE ;

RIESING, S .

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 1990, 4 (03) :189-192

[10] CEREBRAL EXCESS RELEASE OF NEUROTRANSMITTER AMINO-ACIDS SUBSEQUENT TO REDUCED CEREBRAL GLUCOSE-METABOLISM IN EARLY-ONSET DEMENTIA OF ALZHEIMER TYPE [J].

HOYER, S ;

NITSCH, R .

JOURNAL OF NEURAL TRANSMISSION, 1989, 75 (03) :227-232