CORPUS-CALLOSUM - INTERACTIVE EFFECTS OF INFANTILE HANDLING AND TESTOSTERONE IN THE RAT

被引：29

作者：

DENENBERG, VH ^{[1
]}

FITCH, RH ^{[1
]}

SCHROTT, LM ^{[1
]}

COWELL, PE ^{[1
]}

WATERS, NS ^{[1
]}

机构：

[1] UNIV CONNECTICUT,DEPT PSYCHOL,STORRS,CT 06268

来源：

BEHAVIORAL NEUROSCIENCE | 1991年 / 105卷 / 04期

关键词：

D O I：

10.1037/0735-7044.105.4.562

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Previous research found that the corpus callosum of male rats is larger than that of females; handling rats in infancy enhances this sex difference; and female rat pups, when handled in infancy and given 1 injection of testosterone propionate (TP) on Day 4 of life, will have callosa as large as those of males. In 2 experiments, male pups were castrated on Day 1 or received sham surgery; female pups were injected with TP on Day 4 or received an oil injection. Litters were handled or nonhandled. The previous finding that females, when handled and given TP in infancy, have a larger callosum was confirmed; however, a TP effect when administered to nonhandled females was not found. Because handling is known to cause a corticosterone release, these findings were interpreted as evidence of a developmental interaction between adrenal and gonadal hormones at the cortical level.

引用

页码：562 / 566

页数：5

共 26 条

[21] EARLY POSTNATAL HANDLING ALTERS GLUCOCORTICOID RECEPTOR CONCENTRATIONS IN SELECTED BRAIN-REGIONS [J].