PERSISTENCE OF HEPATITIS-B VIRAL-DNA AFTER SEROLOGICAL RECOVERY FROM HEPATITIS-B VIRUS-INFECTION

被引：109

作者：

BLUM, HE ^{[1
]}

LIANG, TJ ^{[1
]}

GALUN, E ^{[1
]}

WANDS, JR ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,GASTROINTESTINAL UNIT,BOSTON,MA 02114

来源：

HEPATOLOGY | 1991年 / 14卷 / 01期

关键词：

D O I：

10.1002/hep.1840140110

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic hepatitis B virus infection is a major medical problem worldwide. Apart from HBsAg carriers, hepatitis B virus has also been identified in some HBsAg- individuals with or without antibodies to viral antigens. The molecular mechanisms underlying hepatitis B virus persistence in HBsAg- individuals are unresolved, however. To identify a possible genetic basis for viral persistence, we cloned the viral genome from the liver of a patient serologically immune to hepatitis B virus infection. DNA sequence analysis of the complete viral genome identified numerous mutations in all viral genes. Analysis of the biological effects of these mutations revealed three major findings: a low level of HBsAg synthesis, absence of HBeAg production and a defect terminating viral replication. These data suggest that mutations accumulating during the natural course of hepatitis B virus infection may be a mechanism underlying viral persistence in HBsAg- individuals, presumably through escape from immune surveillance.

引用

页码：56 / 62

页数：7

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