ADRENOMEDULLIN INHIBITS THE SECRETION OF CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT, A MEMBER OF THE INTERLEUKIN-8 FAMILY, FROM RAT ALVEOLAR MACROPHAGES

被引：81

作者：

KAMOI, H ^{[1
]}

KANAZAWA, H ^{[1
]}

HIRATA, K ^{[1
]}

KURIHARA, N ^{[1
]}

YANO, Y ^{[1
]}

OTANI, S ^{[1
]}

机构：

[1] OSAKA CITY UNIV,SCH MED,DEPT INTERNAL MED 1,ABENO KU,OSAKA 545,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 211卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1914

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was undertaken to determine the effects of adrenomedullin (AM) on the secretion of cytokine-induced neutrophil chemoattractant (CINC), a member of the interleukin-8 family, from lipopolysaccharide-stimulated rat alveolar macrophages in vitro. AM significantly increased cAMP levels in alveolar macrophages in a dose-dependent fashion. On the other hand, AM significantly inhibited CINC secretion from alveolar macrophages in a dose-dependent fashion, and 8-bromo-cyclic adenosine monophosphate (8-Br-cAMP) also significantly inhibited CINC secretion. These findings suggest that AM may play important roles in the regulation of airway inflammation via a cAMP-dependent mechanism. (C) 1995 Academic Press, Inc.

引用

页码：1031 / 1035

页数：5

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