ADRENOMEDULLIN, A NEWLY DISCOVERED HYPOTENSIVE PEPTIDE, IS A POTENT BRONCHODILATOR

被引：95

作者：

KANAZAWA, H

KURIHARA, N

HIRATA, K

KUDOH, S

KAWAGUCHI, T

TAKEDA, T

机构：

[1] First Department of Internai Medicine, Osaka City University Medical School, Osaka 545

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2657

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study was designed to examine the effect of adrenomedullin (AM), a novel vasorelaxant peptide originally isolated from human pheochromocytoma, on histamine-or acetylcholine-induced bronchoconstriction in anesthetized guinea pigs in vivo. AM significantly inhibited acetylcholine-induced bronchoconstriction in a dose-dependent fashion. AM also significantly inhibited histamine-induced bronchoconstriction, but 10(-10) M AM had no significant inhibitory effect on this response. We also found that AM induced a long-lasting bronchodilator response, while isoproterenol induced transient bronchodilation. These preliminary findings suggest that AM may play important roles in airway function. (C) 1994 Academic Press, Inc.

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页码：251 / 254

页数：4

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