LOW CONCENTRATION ENDOTHELIN-1 ENHANCED HISTAMINE-MEDIATED BRONCHIAL CONTRACTIONS OF GUINEA-PIGS INVIVO

被引：18

作者：

KANAZAWA, H

KURIHARA, N

HIRATA, K

FUJIWARA, H

MATSUSHITA, H

TAKEDA, T

机构：

[1] The First Department, Internal Medicine Osaka City University Medical School 1-5-7, 545, Asahi-Machi, Abenoku Osaka

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91254-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelin-1 (ET-1) represents one of the most potent constrictors of guinea pig bronchial smooth muscle. In our study, various doses of aerosolized ET-1 increased airway resistance. But a very low concentration of ET-1 (10-12M) could not change airway resistance. We examined low doses of ET-1 enhanced the sensitivity of bronchial contractions to histamine. ET-1 may play one of the most important roles in contributing directly or indirectly to the pathogenesis of bronchial asthma. © 1992.

引用

页码：717 / 721

页数：5

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