LYSOSOME RECRUITMENT DURING HOST-CELL INVASION BY TRYPANOSOMA-CRUZI

被引：51

作者：

ANDREWS, NW

机构：

[1] Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06510

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(00)88965-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intracellular free Ca2+ occur upon contact of the parasites with host cells ann may contribute to the regulation of this unusual process.

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收藏

页码：133 / 137

页数：5

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