LYSOSOME RECRUITMENT DURING HOST-CELL INVASION BY TRYPANOSOMA-CRUZI

被引：51

作者：

ANDREWS, NW

机构：

[1] Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06510

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(00)88965-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intracellular free Ca2+ occur upon contact of the parasites with host cells ann may contribute to the regulation of this unusual process.

引用

收藏

页码：133 / 137

页数：5

相关论文

共 46 条

[1] INCREASED SYNTHESIS AND SPECIFIC LOCALIZATION OF A MAJOR LYSOSOMAL MEMBRANE SIALOGLYCOPROTEIN (LGP107) AT THE RUFFLED BORDER MEMBRANE OF ACTIVE OSTEOCLASTS [J].

AKAMINE, A ;

TSUKUBA, T ;

KIMURA, R ;

MAEDA, K ;

TANAKA, Y ;

KATO, K ;

YAMAMOTO, K .

HISTOCHEMISTRY, 1993, 100 (02) :101-108

[2]

ALVES MJM, 1986, MOL BIOCHEM PARASIT, V21, P75, DOI 10.1016/0166-6851(86)90081-2

[3] A TRYPANOSOMA-CRUZI SECRETED PROTEIN IMMUNOLOGICALLY RELATED TO THE COMPLEMENT COMPONENT-C9 - EVIDENCE FOR MEMBRANE PORE-FORMING ACTIVITY AT LOW PH [J].

ANDREWS, NW ;

ABRAMS, CK ;

SLATIN, SL ;

GRIFFITHS, G .

CELL, 1990, 61 (07) :1277-1287

[4] ELEVATION OF INTRACELLULAR FREE CALCIUM LEVELS IN HEP-2 CELLS INFECTED WITH ENTEROPATHOGENIC ESCHERICHIA-COLI [J].

BALDWIN, TJ ;

WARD, W ;

AITKEN, A ;

KNUTTON, S ;

WILLIAMS, PH .

INFECTION AND IMMUNITY, 1991, 59 (05) :1599-1604

[5] POLARIZED SECRETION OF LYSOSOMAL-ENZYMES - CO-DISTRIBUTION OF CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTORS AND LYSOSOMAL-ENZYMES ALONG THE OSTEOCLAST EXOCYTIC PATHWAY [J].

BARON, R ;

NEFF, L ;

BROWN, W ;

COURTOY, PJ ;

LOUVARD, D ;

FARQUHAR, MG .

JOURNAL OF CELL BIOLOGY, 1988, 106 (06) :1863-1872

[6] BACILLUS-SUBTILIS EXPRESSING A HEMOLYSIN GENE FROM LISTERIA-MONOCYTOGENES CAN GROW IN MAMMALIAN-CELLS [J].

BIELECKI, J ;

YOUNGMAN, P ;

CONNELLY, P ;

PORTNOY, DA .

NATURE, 1990, 345 (6271) :175-176

[7] MICROFILAMENT STRUCTURE AND FUNCTION IN THE CORTICAL CYTOSKELETON [J].

BRETSCHER, A .

ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 :337-374

[8] REORGANIZATION OF PERIPHERAL ACTIN-FILAMENTS AS A PRELUDE TO EXOCYTOSIS [J].

BURGOYNE, RD ;

CHEEK, TR .

BIOSCIENCE REPORTS, 1987, 7 (04) :281-288

[9]

BURLEIGH B, IN PRESS J BIOL CHEM

[10]

CARVALHO T M U D, 1989, Cell Structure and Function, V14, P383

← 1 2 3 4 5 →