THE WNT FAMILY OF DEVELOPMENTAL REGULATORS

被引：135

作者：

MCMAHON, AP

机构：

来源：

TRENDS IN GENETICS | 1992年 / 8卷 / 07期

关键词：

D O I：

10.1016/0168-9525(92)90122-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since its initial identification in mouse mammary tumors, the proto-oncogene Wnt-1 has been shown to encode a member of a family of putative signalling molecules. Recent work has implicated Wnt-1, and other members of the Wnt gene family, in regulation of a number of basic developmental processes in Drosophila, Xenopus and the mouse. These studies are leading to a new appreciation of the normal and oncogenic actions of Wnt genes.

引用

收藏

页码：236 / 242

页数：7

相关论文

共 59 条

[51] INJECTED XWNT-8 RNA ACTS EARLY IN XENOPUS EMBRYOS TO PROMOTE FORMATION OF A VEGETAL DORSALIZING CENTER [J].

SMITH, WC ;

HARLAND, RM .

CELL, 1991, 67 (04) :753-765

[52] INJECTED WNT RNA INDUCES A COMPLETE BODY AXIS IN XENOPUS EMBRYOS [J].

SOKOL, S ;

CHRISTIAN, JL ;

MOON, RT ;

MELTON, DA .

CELL, 1991, 67 (04) :741-752

[53] The induction of embryonic predispositions by implantation of organizers foreign to the species. [J].

Spemann, H ;

Mangold, H .

ARCHIV FUR MIKROSKOPISCHE ANATOMIE UND ENTWICKLUNGSMECHANIK, 1924, 100 (3/4) :599-638

[54] TARGETED DISRUPTION OF THE MURINE INT-1 PROTOONCOGENE RESULTING IN SEVERE ABNORMALITIES IN MIDBRAIN AND CEREBELLAR DEVELOPMENT [J].

THOMAS, KR ;

CAPECCHI, MR .

NATURE, 1990, 346 (6287) :847-850

[55] SWAYING IS A MUTANT ALLELE OF THE PROTOONCOGENE WNT-1 [J].

THOMAS, KR ;

MUSCI, TS ;

NEUMANN, PE ;

CAPECCHI, MR .

CELL, 1991, 67 (05) :969-976

[56] EXPRESSION OF THE INT-1 GENE IN TRANSGENIC MICE IS ASSOCIATED WITH MAMMARY-GLAND HYPERPLASIA AND ADENOCARCINOMAS IN MALE AND FEMALE MICE [J].

TSUKAMOTO, AS ;

GROSSCHEDL, R ;

GUZMAN, RC ;

PARSLOW, T ;

VARMUS, HE .

CELL, 1988, 55 (04) :619-625

[57] DISTRIBUTION OF THE WINGLESS GENE-PRODUCT IN DROSOPHILA EMBRYOS - A PROTEIN INVOLVED IN CELL-CELL COMMUNICATION [J].

VANDENHEUVEL, M ;

NUSSE, R ;

JOHNSTON, P ;

LAWRENCE, PA .

CELL, 1989, 59 (04) :739-749

[58] STRUCTURE AND NUCLEOTIDE-SEQUENCE OF THE PUTATIVE MAMMARY ONCOGENE INT-1 - PROVIRAL INSERTIONS LEAVE THE PROTEIN-ENCODING DOMAIN INTACT [J].

VANOOYEN, A ;

NUSSE, R .

CELL, 1984, 39 (01) :233-240

[59] EXPRESSION OF THE PROTOONCOGENE INT-1 IS RESTRICTED TO SPECIFIC NEURAL CELLS IN THE DEVELOPING MOUSE EMBRYO [J].

WILKINSON, DG ;

BAILES, JA ;

MCMAHON, AP .

CELL, 1987, 50 (01) :79-88

← 1 2 3 4 5 6 →