THE 3-D STRUCTURE OF HIV-1 PROTEINASE AND THE DESIGN OF ANTIVIRAL AGENTS FOR THE TREATMENT OF AIDS

被引：86

作者：

BLUNDELL, TL

LAPATTO, R

WILDERSPIN, AF

HEMMINGS, AM

HOBART, PM

DANLEY, DE

WHITTLE, PJ

机构：

[1] PFIZER INC,GROTON,CT 06340

[2] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 11期

关键词：

D O I：

10.1016/0968-0004(90)90280-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity. © 1990.

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页码：425 / 430

页数：6

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