PURIFICATION AND CHARACTERIZATION OF THE RAT-LIVER MICROSOMAL CYTOCHROME-P-450 INVOLVED IN THE 4-HYDROXYLATION OF DEBRISOQUINE, A PROTOTYPE FOR GENETIC-VARIATION IN OXIDATIVE DRUG-METABOLISM

被引：198

作者：

LARREY, D

DISTLERATH, LM

DANNAN, GA

WILKINSON, GR

GUENGERICH, FP

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

[2] VANDERBILT UNIV,MED CTR,SCH MED,CTR ENVIRONM TOXICOL,NASHVILLE,TN 37232

[3] VANDERBILT UNIV,MED CTR,SCH MED,DEPT PHARMACOL,NASHVILLE,TN 37232

来源：

BIOCHEMISTRY | 1984年 / 23卷 / 12期

关键词：

D O I：

10.1021/bi00307a039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2787 / 2795

页数：9

共 42 条

[1] ANIMAL MODELING OF HUMAN POLYMORPHIC DRUG OXIDATION - THE METABOLISM OF DEBRISOQUINE AND PHENACETIN IN RAT INBRED STRAINS [J].

ALDABBAGH, SG ;

IDLE, JR ;

SMITH, RL .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1981, 33 (03) :161-164

[2]

BOOBIS AR, 1983, MOL PHARMACOL, V23, P474

[3]

CLEVELAND DW, 1977, J BIOL CHEM, V252, P1102

[4] EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER [J].

DAVIES, DS ;

KAHN, GC ;

MURRAY, S ;

BRODIE, MJ ;

BOOBIS, AR .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (01) :89-91

[5] THE CONTRIBUTION OF GENETICALLY-DETERMINED OXIDATION STATUS TO INTERINDIVIDUAL VARIATION IN PHENACETIN DISPOSITION [J].

DEVONSHIRE, HW ;

KONG, I ;

COOPER, M ;

SLOAN, TP ;

IDLE, JR ;

SMITH, RL .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 16 (02) :157-166

[6] ANTIPYRINE METABOLISM IN RELATION TO POLYMORPHIC OXIDATIONS OF SPARTEINE AND DEBRISOQUINE [J].

EICHELBAUM, M ;

BERTILSSON, L ;

SAWE, J .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 15 (03) :317-321

[7]

EICHELBAUM M, 1982, CLIN PHARMACOKINET, V7, P1, DOI 10.2165/00003088-198207010-00001

[8] PROCEDURE FOR ESTIMATION OF MICROGRAM QUANTITIES OF TRITON X-100 [J].

GAREWAL, HS .

ANALYTICAL BIOCHEMISTRY, 1973, 54 (02) :319-324

[9] PRIMARY AND BETA-SECONDARY DEUTERIUM-ISOTOPE EFFECTS IN O-DEETHYLATION OF PHENACETIN [J].

GARLAND, WA ;

NELSON, SD ;

SASAME, HA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 72 (02) :539-545

[10] SPECTROPHOTOMETRIC ASSAY FOR POLYETHOXY NONIONIC DETERGENTS IN MEMBRANE EXTRACTS - CRITIQUE [J].

GOLDSTEIN, S ;

BLECHER, M .

ANALYTICAL BIOCHEMISTRY, 1975, 64 (01) :130-135

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