TRANSFORMING GROWTH-FACTOR-BETA DIFFERENTIALLY MODULATES THE INDUCIBLE NITRIC-OXIDE SYNTHASE GENE IN DISTINCT CELL-TYPES

被引：73

作者：

GILBERT, RS ^{[1
]}

HERSCHMAN, HR ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, BIOMED & ENVIRONM SCI LAB, LOS ANGELES, CA 90024 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.2054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide is a mediator of paracrine cell signalling. An inducible form of nitric oxide synthase (iNOS) is expressed in macrophages and in Swiss 3T3 cells. Transforming growth factor beta (TGF-beta) is a cytokine that modulates many cellular functions. We find that TGF-beta cannot induce iNOS mRNA expression, either in macrophage cell lines or in Swiss 3T3 cells. However, TGF-beta attenuates lipopolysaccharide induction of iNOS mRNA in macrophages. In contrast, TGF-beta enhances iNOS induction by phorbol ester, serum or lipopolysaccharide in 3T3 cells. Thus TGF-beta can inhibit or augment iNOS mRNA induction in response to primary inducers, depending on the cell type in question. © 1993 Academic Press. All rights reserved.

引用

页码：380 / 384

页数：5

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