BIOSYNTHESIS OF CORTICOTROPIN-RELEASING HORMONE IN HUMAN T-LYMPHOCYTES

被引：94

作者：

EKMAN, R

SERVENIUS, B

CASTRO, MG

LOWRY, PJ

CEDERLUND, AS

BERGMAN, O

SJOGREN, HO

机构：

[1] UNIV LUND,DEPT PSYCHIAT & NEUROCHEM,S-22101 LUND,SWEDEN

[2] UNIV LUND,DEPT MED MOLEC BIOL,S-22101 LUND,SWEDEN

[3] UNIV LUND,DEPT TUMOR IMMUNOL,S-22101 LUND,SWEDEN

[4] DUNDEE INST TECHNOL,DEPT MOLEC & LIFE SCI,DUNDEE,SCOTLAND

[5] UNIV READING,DEPT BIOCHEM & PHYSIOL,READING RG6 2AH,BERKS,ENGLAND

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 44卷 / 01期

关键词：

CORTICOTROPIN-RELEASING HORMONE; BIOSYNTHESIS; T-LYMPHOCYTES;

D O I：

10.1016/0165-5728(93)90262-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Corticotropin-releasing hormone (CRH) is a 41-amino acid neuropeptide which increases the transcription of the proopiomelanocortin (POMC) gene, as well as the biosynthesis and secretion of POMC-derived peptides. Using a specific human CRH radioimmunoassay we have shown that human T-lymphocytes contain immunoreactive CRH. We studied the effects of phytohemagglutinin (PHA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the biosynthesis of CRH in human T-lymphocyte cell cultures. A significant increase in CRH mRNA levels was observed in human lymphocytes after 12 h of PHA/TPA treatment, while the levels decreased after 22 h. These findings could imply an immunomodulatory role for CRH that could be due to autocrine and/or paracrine interactions.

引用

页码：7 / 14

页数：8

共 29 条

[1] HYPOTHALAMIC CONTROL OF ADRENOCORTICOTROPIN SECRETION - ADVANCES SINCE THE DISCOVERY OF 41-RESIDUE CORTICOTROPIN-RELEASING FACTOR [J].