LONG-TERM DEPRESSION REQUIRES NITRIC-OXIDE AND GUANOSINE 3'/5' CYCLIC MONOPHOSPHATE PRODUCTION IN RAT CEREBELLAR PURKINJE-CELLS

被引：131

作者：

DANIEL, H ^{[1
]}

HEMART, N ^{[1
]}

JAILLARD, D ^{[1
]}

CREPEL, F ^{[1
]}

机构：

[1] UNIV PARIS 11,CNRS,URA 1121,BAT 440,F-91405 ORSAY,FRANCE

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1993年 / 5卷 / 08期

关键词：

SYNAPTIC PLASTICITY; CEREBELLUM; EXCITATORY AMINO ACID RECEPTORS; NITRIC OXIDE;

D O I：

10.1111/j.1460-9568.1993.tb00961.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In patch-clamped Purkinje cells, bath application of the nitric oxide synthase inhibitor N(G)-methyl-L-arginine consistently prevents the induction of long-term depression (LTD) of parallel fibre-mediated excitatory postsynaptic potentials (EPSPs) induced by their pairing with calcium spikes. On the other hand, bath application of nitric oxide donors and of 8-bromoguanosine 3':5' cyclic monophosphate is able to reproduce an LTD-like phenomenon. LTD of parallel fibre-mediated EPSPs also occurs when nitric oxide donors or guanosine 3':5' cyclic monophosphate are directly dialysed into Purkinje cells, and this effect partially occludes LTD induced by pairing protocols, These results show that nitric oxide does play a role in LTD induction, and demonstrate for the first time that its site of action is probably the soluble guanylate cyclase of Purkinje cells.

引用

页码：1079 / 1082

页数：4