LONG-TERM DEPRESSION REQUIRES NITRIC-OXIDE AND GUANOSINE 3'/5' CYCLIC MONOPHOSPHATE PRODUCTION IN RAT CEREBELLAR PURKINJE-CELLS

被引：131

作者：

DANIEL, H ^{[1
]}

HEMART, N ^{[1
]}

JAILLARD, D ^{[1
]}

CREPEL, F ^{[1
]}

机构：

[1] UNIV PARIS 11,CNRS,URA 1121,BAT 440,F-91405 ORSAY,FRANCE

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1993年 / 5卷 / 08期

关键词：

SYNAPTIC PLASTICITY; CEREBELLUM; EXCITATORY AMINO ACID RECEPTORS; NITRIC OXIDE;

D O I：

10.1111/j.1460-9568.1993.tb00961.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In patch-clamped Purkinje cells, bath application of the nitric oxide synthase inhibitor N(G)-methyl-L-arginine consistently prevents the induction of long-term depression (LTD) of parallel fibre-mediated excitatory postsynaptic potentials (EPSPs) induced by their pairing with calcium spikes. On the other hand, bath application of nitric oxide donors and of 8-bromoguanosine 3':5' cyclic monophosphate is able to reproduce an LTD-like phenomenon. LTD of parallel fibre-mediated EPSPs also occurs when nitric oxide donors or guanosine 3':5' cyclic monophosphate are directly dialysed into Purkinje cells, and this effect partially occludes LTD induced by pairing protocols, These results show that nitric oxide does play a role in LTD induction, and demonstrate for the first time that its site of action is probably the soluble guanylate cyclase of Purkinje cells.

引用

页码：1079 / 1082

页数：4

共 21 条

[1] A ROLE FOR NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

BON, C ;

BOHME, GA ;

DOBLE, A ;

STUTZMANN, JM ;

BLANCHARD, JC .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (05) :420-424

[2] LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].

BREDT, DS ;

HWANG, PM ;

SNYDER, SH .

NATURE, 1990, 347 (6295) :768-770

[3] PAIRING OF PRESYNAPTIC AND POSTSYNAPTIC ACTIVITIES IN CEREBELLAR PURKINJE-CELLS INDUCES LONG-TERM CHANGES IN SYNAPTIC EFFICACY INVITRO [J].

CREPEL, F ;

JAILLARD, D .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 432 :123-141

[4] ACTIVATION OF PROTEIN KINASE-C INDUCES A LONG-TERM DEPRESSION OF GLUTAMATE SENSITIVITY OF CEREBELLAR PURKINJE-CELLS - AN INVITRO STUDY [J].

CREPEL, F ;

KRUPA, M .

BRAIN RESEARCH, 1988, 458 (02) :397-401

[5]

Crepel F, 1990, Neuroreport, V1, P133, DOI 10.1097/00001756-199010000-00013

[6]

DANIEL H, 1992, EXP BRAIN RES, V90, P327

[7]

ECCLES JC, 1967, CEREBELLUM AS NEURON

[8] A KAINATE RECEPTOR LINKED TO NITRIC-OXIDE SYNTHESIS FROM ARGININE [J].

GARTHWAITE, J ;

SOUTHAM, E ;

ANDERTON, M .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (06) :1952-1954

[9] LONG-TERM DEPRESSION [J].

ITO, M .

ANNUAL REVIEW OF NEUROSCIENCE, 1989, 12 :85-102

[10]

Ito M, 1990, Neuroreport, V1, P129

← 1 2 3 →