THE IMMUNOGLOBULIN HEAVY-CHAIN ENHANCER IS STIMULATED BY THE ADENOVIRUS TYPE-2 E1A PRODUCTS IN MOUSE FIBROBLASTS

被引：49

作者：

BORRELLI, E

HEN, R

WASYLYK, C

WASYLYK, B

CHAMBON, P

机构：

[1] FAC MED STRASBOURG, CNRS, GENET MOLEC EUCARYOTES LAB, 11 RUE HUMANN, F-67085 STRASBOURG, FRANCE

[2] FAC MED STRASBOURG, INSERM, UNITE BIOL MOLEC & GENIE GENET 184, F-67085 STRASBOURG, FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1986年 / 83卷 / 09期

关键词：

D O I：

10.1073/pnas.83.9.2846

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In contrast with our previous results (Hen, R., Borrelli, E. and Chambon, P. (185) Science 230, 1391-1394), which demonstrated that the mouse immunoglobulin heavy chain transcriptional enhancer is repressed in lymphoid cells by the products of the adenovirus type 2 E1A transcription unit, we show here that these products activate the same enhancer in mouse fibroblast L cell lines that contain stably integrated copies of a recombinant in which the enhancer is inserted upstream from the chicken conalbumin promoter. In addition, competition experiments suggest that the activity of the heavy chain enhancer may be repressed by a trans-acting factor in mouse L cells. We speculate that the E1A products may prevent the action of this cellular repressor in these cells.

引用

页码：2846 / 2849

页数：4

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