CONGO-RED PROTECTS AGAINST TOXICITY OF BETA-AMYLOID PEPTIDES ON RAT HIPPOCAMPAL-NEURONS

被引：46

作者：

BURGEVIN, MC ^{[1
]}

PASSAT, M ^{[1
]}

DANIEL, N ^{[1
]}

CAPET, M ^{[1
]}

DOBLE, A ^{[1
]}

机构：

[1] RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,DEPT CHEM,F-94403 VITRY,FRANCE

来源：

NEUROREPORT | 1994年 / 5卷 / 18期

关键词：

BETA-AMYLOID; CONGO RED; AMYLIN; NEUROTOXICITY; CULTURED NEURONS; AGGREGATION; HIPPOCAMPUS; RAT;

D O I：

10.1097/00001756-199412000-00006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

beta-AMYLOID peptides are neurotoxic when applied to primary cultures of hippocampal neurones from the embryonic rat. This neurotoxic effect can be inhibited completely by certain disazo dyestuffs. The most potent of these are Congo Red and Congo Rubin, whilst Direct Garnet and sodium 4-aminonaphthalene-1-sulphonate are inactive. Congo Red also inhibits the neurotoxic effects of the human pancreatic amyloidogenic peptide amylin. It is postulated that these dyes, by interacting with the beta-pleated sheet structure of amyloidogenic peptides, prevent aggregation and hence neurotoxity.

引用

页码：2429 / 2432

页数：4

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