ROLES OF MOLECULAR CHAPERONES IN PROTEIN-FOLDING

被引：70

作者：

ELLIS, RJ

机构：

[1] Department of Biological Sciences, University of Warwick, Coventry

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(94)90069-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The idea that in living cells, proteins fold spontaneously in an energy-independent fashion, as they can in vitro, is being replaced by the concept that protein folding in vivo is assisted by pre-existing proteins called molecular chaperones, some of which hydrolyse ATP. The mechanism of action of some of these molecular chaperones has recently been better defined, and confirms the view that they act not by providing steric information but by minimizing the formation of misfolded structures.

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页码：117 / 122

页数：6

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