ROLES OF MOLECULAR CHAPERONES IN PROTEIN-FOLDING

被引：70

作者：

ELLIS, RJ

机构：

[1] Department of Biological Sciences, University of Warwick, Coventry

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(94)90069-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The idea that in living cells, proteins fold spontaneously in an energy-independent fashion, as they can in vitro, is being replaced by the concept that protein folding in vivo is assisted by pre-existing proteins called molecular chaperones, some of which hydrolyse ATP. The mechanism of action of some of these molecular chaperones has recently been better defined, and confirms the view that they act not by providing steric information but by minimizing the formation of misfolded structures.

引用

收藏

页码：117 / 122

页数：6

相关论文

共 50 条

[1] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS [J].

ANFINSEN, CB .

SCIENCE, 1973, 181 (4096) :223-230

[2] PROTEIN-SYNTHESIS IN CHLOROPLASTS .9. ASSEMBLY OF NEWLY-SYNTHESIZED LARGE SUBUNITS INTO RIBULOSE BISPHOSPHATE CARBOXYLASE IN ISOLATED INTACT PEA-CHLOROPLASTS [J].

BARRACLOUGH, R ;

ELLIS, RJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 608 (01) :19-31

[3] IDENTIFICATION, CHARACTERIZATION, AND DNA-SEQUENCE OF A FUNCTIONAL DOUBLE GROES-LIKE CHAPERONIN FROM CHLOROPLASTS OF HIGHER-PLANTS [J].

BERTSCH, U ;

SOLI, J ;

SEETHARAM, R ;

VIITANEN, PV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8696-8700

[4] AFFINITY PANNING OF A LIBRARY OF PEPTIDES DISPLAYED ON BACTERIOPHAGES REVEALS THE BINDING-SPECIFICITY OF BIP [J].

BLONDELGUINDI, S ;

CWIRLA, SE ;

DOWER, WJ ;

LIPSHUTZ, RJ ;

SPRANG, SR ;

SAMBROOK, JF ;

GETHING, MJH .

CELL, 1993, 75 (04) :717-728

[5]

BOCHKAREVA ES, 1992, J BIOL CHEM, V267, P6796

[6]

BOCHKAREVA ES, 1992, J BIOL CHEM, V267, P25672

[7] A POLYPEPTIDE BOUND BY THE CHAPERONIN GROEL IS LOCALIZED WITHIN A CENTRAL CAVITY [J].

BRAIG, K ;

SIMON, M ;

FURUYA, F ;

HAINFELD, JF ;

HORWICH, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :3978-3982

[8] THE CONSTITUTIVE AND STRESS INDUCIBLE FORMS OF HSP-70 EXHIBIT FUNCTIONAL SIMILARITIES AND INTERACT WITH ONE ANOTHER IN AN ATP-DEPENDENT FASHION [J].

BROWN, CR ;

MARTIN, RL ;

HANSEN, WJ ;

BECKMANN, RP ;

WELCH, WJ .

JOURNAL OF CELL BIOLOGY, 1993, 120 (05) :1101-1112

[9]

CAPLAN A, 1994, IN PRESS MOL CELL BI

[10] PROTEINS AS MOLECULAR CHAPERONES [J].

ELLIS, J .

NATURE, 1987, 328 (6129) :378-379

← 1 2 3 4 5 →