NITRIC-OXIDE AND ITS ROLE IN THE CARDIOVASCULAR-SYSTEM

被引：505

作者：

LOSCALZO, J ^{[1
]}

WELCH, G ^{[1
]}

机构：

[1] BOSTON UNIV, SCH MED, EVANS DEPT MED, WHITAKER CARDIOVASC INST, BOSTON, MA 02118 USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 1995年 / 38卷 / 02期

关键词：

D O I：

10.1016/S0033-0620(05)80001-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types and organ systems. In the cardiovascular system, NO is an important determinant of basal vascular tone, prevents platelet activation, limits leukocyte adhesion to the endothelium, and regulates myocardial contractility. NO may also play a role in the pathogenesis of common cardiovascular disorders, including hypotension accompanying shock states, essential hypertension, and atherosclerosis. In this review, we discuss the biochemistry of NO and focus on its biology and pathophysiology in the cardiovascular system. © 1995 W.B. Saunders Company. All rights reserved.

引用

页码：87 / 104

页数：18

共 167 条

[61] BIOLOGICAL ACTIONS AND PROPERTIES OF ENDOTHELIUM-DERIVED NITRIC-OXIDE FORMED AND RELEASED FROM ARTERY AND VEIN [J].

IGNARRO, LJ .

CIRCULATION RESEARCH, 1989, 65 (01) :1-21

[62] ENDOTHELIUM-DERIVED RELAXING FACTOR PRODUCED AND RELEASED FROM ARTERY AND VEIN IS NITRIC-OXIDE [J].

IGNARRO, LJ ;

BUGA, GM ;

WOOD, KS ;

BYRNS, RE ;

CHAUDHURI, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :9265-9269

[63] ENDOTHELIUM-DERIVED RELAXING FACTOR FROM PULMONARY-ARTERY AND VEIN POSSESSES PHARMACOLOGICAL AND CHEMICAL-PROPERTIES IDENTICAL TO THOSE OF NITRIC-OXIDE RADICAL [J].

IGNARRO, LJ ;

BYRNS, RE ;

BUGA, GM ;

WOOD, KS .

CIRCULATION RESEARCH, 1987, 61 (06) :866-879

[64]

IKEBE M, 1990, J BIOL CHEM, V265, P8975

[65] CARDIOPROTECTIVE EFFECTS OF AUTHENTIC NITRIC-OXIDE IN MYOCARDIAL-ISCHEMIA WITH REPERFUSION [J].

JOHNSON, G ;

TSAO, PS ;

LEFER, AM .

CRITICAL CARE MEDICINE, 1991, 19 (02) :244-252

[66] IMPAIRED ENDOTHELIUM-DEPENDENT VASODILATION IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

JOHNSTONE, MT ;

CREAGER, SJ ;

SCALES, KM ;

CUSCO, JA ;

LEE, BK ;

CREAGER, MA .

CIRCULATION, 1993, 88 (06) :2510-2516

[67] METHYLENE-BLUE REVERSES ENDOTOXIN-INDUCED HYPOTENSION [J].

KEANEY, JF ;

PUYANA, JC ;

FRANCIS, S ;

LOSCALZO, JF ;

STAMLER, JS ;

LOSCALZO, J .

CIRCULATION RESEARCH, 1994, 74 (06) :1121-1125

[68] NO FORMS AN ADDUCT WITH SERUM-ALBUMIN THAT HAS ENDOTHELIUM-DERIVED RELAXING FACTOR LIKE PROPERTIES [J].

KEANEY, JF ;

SIMON, DI ;

STAMLER, JS ;

JARAKI, O ;

SCHARFSTEIN, J ;

VITA, JA ;

LOSCALZO, J .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1582-1589

[69] QUANTITATIVE AND KINETIC CHARACTERIZATION OF NITRIC-OXIDE AND EDRF RELEASED FROM CULTURED ENDOTHELIAL-CELLS [J].

KELM, M ;

FEELISCH, M ;

SPAHR, R ;

PIPER, HM ;

NOACK, E ;

SCHRADER, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (01) :236-244

[70] CONTROL OF CORONARY VASCULAR TONE BY NITRIC-OXIDE [J].

KELM, M ;

SCHRADER, J .

CIRCULATION RESEARCH, 1990, 66 (06) :1561-1575

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