NITRIC-OXIDE AND ITS ROLE IN THE CARDIOVASCULAR-SYSTEM

被引：505

作者：

LOSCALZO, J ^{[1
]}

WELCH, G ^{[1
]}

机构：

[1] BOSTON UNIV, SCH MED, EVANS DEPT MED, WHITAKER CARDIOVASC INST, BOSTON, MA 02118 USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 1995年 / 38卷 / 02期

关键词：

D O I：

10.1016/S0033-0620(05)80001-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types and organ systems. In the cardiovascular system, NO is an important determinant of basal vascular tone, prevents platelet activation, limits leukocyte adhesion to the endothelium, and regulates myocardial contractility. NO may also play a role in the pathogenesis of common cardiovascular disorders, including hypotension accompanying shock states, essential hypertension, and atherosclerosis. In this review, we discuss the biochemistry of NO and focus on its biology and pathophysiology in the cardiovascular system. © 1995 W.B. Saunders Company. All rights reserved.

引用

页码：87 / 104

页数：18

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