QUATERNARY DERIVATIVES OF NARCOTIC-ANTAGONISTS - STEREOCHEMICAL REQUIREMENTS AT THE CHIRAL NITROGEN FOR INVITRO AND INVIVO ACTIVITY

被引：19

作者：

BIANCHETTI, A ^{[1
]}

NISATO, D ^{[1
]}

SACILOTTO, R ^{[1
]}

DRAGONETTI, M ^{[1
]}

PICERNO, N ^{[1
]}

TARANTINO, A ^{[1
]}

MANARA, L ^{[1
]}

ANGEL, LM ^{[1
]}

SIMON, EJ ^{[1
]}

机构：

[1] NYU,SCH MED,DEPT PSYCHIAT & PHARMACOL,NEW YORK,NY 10016

来源：

LIFE SCIENCES | 1983年 / 33卷

关键词：

D O I：

10.1016/0024-3205(83)90530-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：415 / 418

页数：4

共 10 条

[1] PHARMACOLOGICAL ACTIONS OF LEVALLORPHAN ALLYL BROMIDE (CM-32191), A NEW PERIPHERAL NARCOTIC-ANTAGONIST [J].

BIANCHETTI, A ;

GIUDICE, A ;

PICERNO, N ;

CARMINATI, P .

LIFE SCIENCES, 1982, 31 (20-2) :2261-2264

[2] QUATERNARY NARCOTIC-ANTAGONISTS RELATIVE ABILITY TO PREVENT ANTINOCICEPTION AND GASTROINTESTINAL TRANSIT INHIBITION IN MORPHINE-TREATED RATS AS AN INDEX OF PERIPHERAL SELECTIVITY [J].

BIANCHI, G ;

FIOCCHI, R ;

TAVANI, A ;

MANARA, L .

LIFE SCIENCES, 1982, 30 (22) :1875-1883

[3] EFFECTS OF NALOXONE AND ITS QUATERNARY ANALOG ON STIMULATION-INDUCED FEEDING [J].

CARR, KD ;

SIMON, EJ .

NEUROPHARMACOLOGY, 1983, 22 (01) :127-130

[4]

DRAGONETTI M, 1983, LIFE SCI S1, V33

[5] OPIATE RECEPTOR - MODEL EXPLAINING STRUCTURE-ACTIVITY-RELATIONSHIPS OF OPIATE AGONISTS AND ANTAGONISTS [J].

FEINBERG, AP ;

CREESE, I ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (11) :4215-4219

[6] N-METHYLNALORPHINE - DEFINITION OF N-ALLYL CONFORMATION FOR ANTAGONISM AT THE OPIATE RECEPTOR [J].

KOBYLECKI, RJ ;

LANE, AC ;

SMITH, CFC ;

WAKELIN, LPG ;

CRUSE, WBT ;

EGERT, E ;

KENNARD, O .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (11) :1278-1280

[7]

KOCZKA K, 1967, ACTA CHIM HUNG, V51, P393

[8] KINETIC PARAMETERS OF NARCOTIC AGONISTS AND ANTAGONISTS WITH PARTICULAR REFERENCE TO N-ALLYLNOROXYMORPHONE (NALOXONE) [J].

KOSTERLITZ, HW ;

WATT, AJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1968, 33 (02) :266-+

[9] INVITRO MODELS IN STUDY OF STRUCTURE-ACTIVITY-RELATIONSHIPS OF NARCOTIC ANALGESICS [J].

KOSTERLITZ, HW ;

WATERFIELD, AA .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1975, 15 :29-47

[10]

SIMON EJ, 1975, J PHARMACOL EXP THER, V192, P531

← 1 →