THE PHARMACOLOGY OF INTRACELLULAR CA2+-RELEASE CHANNELS

被引：412

作者：

EHRLICH, BE

KAFTAN, E

BEZPROZVANNAYA, S

BEZPROZVANNY, I

机构：

[1] UNIV CONNECTICUT, DEPT PHYSIOL, FARMINGTON, CT 06032 USA

[2] STANFORD UNIV, MED CTR, BECKMAN CTR, DEPT MOLEC & CELLULAR PHYSIOL, STANFORD, CA 94305 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1994年 / 15卷 / 05期

关键词：

D O I：

10.1016/0165-6147(94)90074-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two classes of intracellular Ca2+-release channels, the ryanodine receptor and the inositol (1,4,5)-trisphosphate (IP3) receptor, are essential for spatio-temporal Ca2+ signalling in cells. Heparin and caffeine have been widely used to study these channels. It was originally thought that caffeine acts solely as an agonist for the ryanodine receptor and heparin acts solely as an inhibitor for the IP3 receptor. However, recent experiments indicate that these compounds have multiple effects, and are discussed in this review by Barbara Ehrlich and colleagues. In the same concentration range, caffeine activates the ryanodine receptor and inhibits the IP3 receptor, and heparin inhibits the IP3 receptor and activates the ryanodine receptor. More specific pharmacological tools that are suitable for studies of ryanodine and IP3 receptors are now beginning to emerge.

引用

页码：145 / 149

页数：5

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[1] ACTIVATION AND CONDUCTANCE PROPERTIES OF RYANODINE-SENSITIVE CALCIUM CHANNELS FROM BRAIN MICROSOMAL-MEMBRANES INCORPORATED INTO PLANAR LIPID BILAYERS [J].